Pentoxifylline changes the shape of red blood cells in your blood. This makes it easier for these blood cells to fit into small arteries (blood vessels). Pentoxifylline is used to improve blood flow. Improved blood flow helps to reduce leg cramps and other symptoms of vascular disease (disease related to veins and arteries). Pentoxifylline may also be used for purposes other than those listed in this medication guide.

The health and medical information provided here is for general purposes only and is not a substitute for the expertise and judgment of your physician, or other health care professional. It should not be understood to indicate that the use of this medicine is safe, appropriate or effective for you. Always consult your health care professional before using this, or any other, drug.

Do not break, crush, or chew the tablets. Swallow them whole. They are specially coated to protect your stomach.
Do not stop taking this medication suddenly. It may take up to 8 weeks for you to see beneficial effects from pentoxifylline.
Tobacco may worsen your condition or decrease the beneficial effects of pentoxifylline by narrowing your blood vessels. Talk to your doctor or pharmacist if you have a tobacco habit.

If you experience any of the following serious side effects, stop taking pentoxifylline and seek medical attention:
an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
chest pain or an irregular heartbeat;
severe dizziness, headache, nosebleeds, or blurred vision;
nausea or vomiting; or
swollen feet or ankles.
Other, less serious side effects may be more likely to occur. Continue to take pentoxifylline and talk to your doctor if you experience
insomnia,
red eyes, or
nervousness.

Take pentoxifylline exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.
Take each dose with a full glass (8 ounces) of water. Take pentoxifylline with food or an antacid to lessen stomach upset.
Pentoxifylline is usually taken three times a day. Follow your doctor`s instructions. If you experience side effects, talk to your doctor. You may only need to take pentoxifylline twice a day.
Do not break, crush, or chew the tablets. Swallow them whole. They are specially coated to protect your stomach.
Do not stop taking this medication suddenly. It may take up to 8 weeks for you to see the beneficial effects of pentoxifylline, although you may begin to feel better as soon as 2 weeks after starting therapy.
Store pentoxifylline at room temperature away from moisture and heat.