Vytorin contains a combination ezetimibe and simvastatin. Ezetimibe reduces the amount of cholesterol absorbed by the body. Simvastatin is in a group of drugs called HMG CoA reductase inhibitors, or "statins." Vytorin reduces levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL). Vytorin is used to treat high cholesterol in adults and children who are at least 10 years old.

The health and medical information provided here is for general purposes only and is not a substitute for the expertise and judgment of your physician, or other health care professional. It should not be understood to indicate that the use of this medicine is safe, appropriate or effective for you. Always consult your health care professional before using this, or any other, drug.

You should not take Vytorin if you are allergic to ezetimibe or simvastatin, if you are pregnant or breast-feeding, or if you have liver disease. Stop taking Vytorin and tell your doctor right away if you become pregnant.
Before taking Vytorin, tell your doctor if you have ever had liver or kidney disease, diabetes, or a thyroid disorder, if you are of Chinese descent, or if you drink more than 2 alcoholic beverages daily.
In rare cases, Vytorin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.
Avoid eating foods that are high in fat or cholesterol. Vytorin will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.
Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage.
There are many other drugs that can increase your risk of serious medical problems if you take them together with Vytorin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.
Vytorin is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

Get emergency medical help if you have any of these signs of an allergic reaction to Vytorin: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking Vytorin and call your doctor at once if you have any of these serious side effects:
unexplained muscle pain, tenderness, or weakness;
fever, unusual tiredness, and dark colored urine;
swelling, weight gain, urinating less than usual or not at all; or
nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious Vytorin side effects may include:
headache, memory problems;
mild muscle pain;
joint pain;
numbness or tingly feeling;
diarrhea;
dizziness, depressed mood;
sleep problems (insomnia); or
cold symptoms such as stuffy nose, sneezing, sore throat.

Take Vytorin exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Vytorin is usually taken once daily in the evening, with or without food. Your doctor may occasionally change your dose to make sure you get the best results.
You may need to stop using Vytorin for a short time if you have surgery or a medical emergency.
To be sure Vytorin is helping your condition and is not causing harmful effects, your blood will need to be tested often. Your liver function may also need to be tested. Visit your doctor regularly.
Vytorin is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.
You may need to take Vytorin on a long-term basis for the treatment of high cholesterol. Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.