Zyprexa (olanzapine) is an atypical antipsychotic medication. Exactly how it works is not known. It is thought to work by changing the actions of certain chemicals in the brain.
Zyprexa is used to treat the symptoms of psychotic conditions such as schizophrenia and bipolar disorder (manic depression) in adults and children who are at least 13 years old.
Zyprexa is sometimes used together with other antipsychotic medications or antidepressants.
Zyprexa may also be used for other purposes not listed in this medication guide.

The health and medical information provided here is for general purposes only and is not a substitute for the expertise and judgment of your physician, or other health care professional. It should not be understood to indicate that the use of this medicine is safe, appropriate or effective for you. Always consult your health care professional before using this, or any other, drug.

Zyprexa is not for use in psychotic conditions related to dementia. Zyprexa may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.

You may gain weight or have high cholesterol and triglycerides (types of fat) while taking this medicine, especially if you are a teenager. Your blood may need to be tested often. Visit your doctor regularly.

Zyprexa can cause high blood sugar (hyperglycemia). If you are diabetic, check your blood sugar levels on a regular basis while you are taking Zyprexa.

Zyprexa may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Avoid drinking alcohol while taking Zyprexa. Avoid becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking Zyprexa.

Get emergency medical help if you have any of these signs of an allergic reaction to Zyprexa: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using Zyprexa and call your doctor at once if you have any of these serious side effects:

very stiff (rigid) muscles, high fever, tremors, sweating, confusion, fast or uneven heartbeats, slow heart rate, feeling like you might pass out;

twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;

trouble speaking or swallowing;

dry mouth, thirst, feeling very hot (with or without sweating), urinating less than usual or not at all;

high blood sugar (increased thirst, loss of appetite, fruity breath odor, increased urination, drowsiness, dry skin, nausea, and vomiting);

sudden numbness or weakness, confusion, or problems with vision, speech, or balance;

fever, chills, body aches, flu symptoms, sores in your mouth and throat;

swelling in your hands or feet;

changes in personality, unusual thoughts or behavior, hallucinations, or thoughts about hurting yourself; or

upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious Zyprexa side effects may include:

weight gain (more likely in teenagers), increased appetite;

headache, dizziness, drowsiness, feeling tired or restless;

memory problems;

stomach pain, constipation, loss of bladder control;

back pain, pain in your arms or legs;

numbness or tingly feeling;

breast swelling or discharge (in women or men); or

missed menstrual periods.

Take Zyprexa exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.

Zyprexa can be taken with or without food.

Zyprexa is usually taken once a day. This medicine may be only part of a complete program of treatment that also includes counseling and other psychological support programs. Follow your doctor`s instructions.

Call your doctor if your symptoms do not improve, or if they get worse while using Zyprexa. Do not stop taking Zyprexa suddenly without first talking to your doctor, even if you feel fine. You may have serious side effects if you stop taking Zyprexa suddenly.

To take olanzapine orally disintegrating tablets (Zyprexa Zydis):

Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil from the tablet blister. Do not push a tablet through the foil or you may damage the tablet.

Using dry hands, remove the tablet and place it in your mouth. It will begin to dissolve right away.

Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.

Swallow several times as the tablet dissolves. If desired, you may drink liquid to help swallow the dissolved tablet.

Zyprexa can cause high blood sugar (hyperglycemia). If you are diabetic, check your blood sugar levels on a regular basis while you are taking Zyprexa.

You may gain weight or have high cholesterol and triglycerides (types of fat) while taking this medicine, especially if you are a teenager. Your blood may need to be tested often. Visit your doctor regularly.

If you are taking a combination of drugs, use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor`s advice.

Store at room temperature away from moisture, heat, and light.